Journal: Microbiology Spectrum
Article Title: Dronedarone synergizes with colistin against planktonic and biofilm forms of multidrug-resistant Gram-negative pathogens
doi: 10.1128/spectrum.03006-25
Figure Lengend Snippet: Time-kill assay demonstrating the efficacy of the COL/DRO combination against carbapenem-resistant MDR-GNP. Bacteria were treated with DRO (8 µg/mL) alone and in combination with COL (0.25× MIC). Bacteria were also treated with COL at 2× MIC alone. ( A ) P. aeruginosa NR51547, ( B ) A. baumannii BAA-1605, ( C ) E. coli BAA-2452 and ( D ) K. pneumoniae BAA-1705. Experiments were done in three biological replicates per each treatment. Data are shown as the mean ± SEM ( N = 3 replicates).
Article Snippet: A. baumanii ATCC BAA-1605 , Isolated from sputum of military personnel returning from Afghanistan entering a Canadian hospital 2006. A multidrug-resistant strain resistant to ceftazidime, gentamicin, ticarcillin, piperacillin, aztreonam, cefepime, ciprofloxacin, imipenem, and meropenem.
Techniques: Time-Kill Assay, Bacteria